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br Acknowledgments br Introduction Sickle cell disease SCD
2018-10-23
Acknowledgments Introduction Sickle cell disease (SCD) is one of the commonest severe inherited disorders affecting millions of people worldwide (Piel et al., 2013). Complications of the disease arise from the presence in patients\' red cells of the abnormal haemoglobin (Hb), HbS, which has a
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Beyond this fundamental research context independent studies
2018-10-23
Beyond this fundamental research context, independent studies confirmed an association of MSRV expression with MS (Perron et al., 2012; Sotgiu et al., 2010). Its envelope protein (MSRV-Env) was shown to elicit pro-inflammatory and autoimmune responses in immune cytotoxicity (Perron et al., 2001, 201
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br Materials and Methods br Results br Discussion Even
2018-10-23
Materials and Methods Results Discussion Even though T cell checkpoint inhibitors alone have achieved impressive clinical benefit in some cancers, their application as single agents has had limited efficacy (Hamid et al., 2013; Wolchok et al., 2013). The resistance to immunotherapy is in pa
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Most of our DSAs were de novo and their development
2018-10-23
Most of our DSAs were “de-novo”, and their development was predicted by donor and recipient ages. Other studies reported younger age at LT and medication non-compliance to be predisposing factors, which was not confirmed in our cohort (Del et al., 2014). Only three children developed both Class II D
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imatinib mesylate Introduction In st century the century
2018-10-23
Introduction In 21st century, the century when the humanity hopes to embark on interplanetary travel, we are yet to fully reach an understanding of our very own idiosyncratic terra incognita – the human sleep. Sleep is a highly conserved evolutionary process that constitutes approximately one third
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br Materials and Methods br Results br Conclusion Our
2018-10-23
Materials and Methods Results Conclusion Our meta-analysis suggested that DNMT1 rs16999593 and DNMT3A rs1550117 could contribute to GC and that DNMT3B rs1569686 might function as a protective factor against gastric carcinogenesis. By using these significant SNPs as biomarkers, it is feasibl
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We identified two critical events that might be associated w
2018-10-23
We identified two critical events that might be associated with pathomechanism collagen VI deficiency in our mice. The first event is a non-cell-autonomous effect from the collagen VI deficiency, causing the dysregulation in the number of myofibers in a muscle. In normal control mice, myofibers incr
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Our results indicate that the antibody response to flaviviru
2018-10-23
Our results indicate that the antibody response to flavivirus NS1 is more virus-type specific than to the E protein. These results encourage future studies to identify NS1 epitopes (linear and conformational) that could be used for virus-specific serologic diagnosis. If the virus-specific epitopes a
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br Funding Sources This study was supported by the
2018-10-23
Funding Sources This study was supported by the grant of State Clinical Key Specialty Construction Project (Pediatric Surgery) 2013 (No.: GJLCZD1301) and the grant of Clinical Medicine Research and Transformation Center of Brain Injury in Premature Infant in Guangzhou (No.: 520101-2150092). The f
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Disclosure br Zika virus ZIKV is a mosquito borne
2018-10-23
Disclosure Zika virus (ZIKV) is a mosquito-borne flavivirus and although it has been known for decades it largely remained obscured and cases were reported only sporadically (). In 2007, the situation changed dramatically upon the first large outbreak of ZIKV in the state of Yap, Federated States
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Though protective against the target diseases DTP may increa
2018-10-23
Though protective against the target diseases, DTP may increase susceptibility to unrelated infections (Aaby et al., 2003b, 2004a, 2012) (Appendix A). The SAGE review noticed that the majority of studies found a detrimental effect of DTP (Higgins et al., 2014). However, SAGE considered the evidence
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The established TDF resistance mutations K
2018-10-23
The established TDF-resistance mutations K65R and K70E have been shown to attenuate virus indole-3-carbinol in vitro and in animal models (Miller et al., 2002; Van Rompay et al., 2007; White et al., 2002; Sluis-Cremer et al., 2007). To determine whether these and other TDF-selected TRAMs are associ
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p450 inhibitors Other studies have examined the utility of a
2018-10-23
Other studies have examined the utility of absolute blood counts in predicting survival of advanced melanoma patients. In a cohort of patients with stage III–IV melanoma treated with surgical resection, absolute lymphocyte count (ALC), a component of NLR, was associated with PFS but not OS in stage
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High oxidative stress and DNA damage activity are
2018-10-23
High oxidative stress and DNA damage activity are increased, while the anti-oxidant enzyme levels are decreased in MM patients (Mehdi et al., 2013). Several free radical drugs, such as As2O3 and ascorbic acid, have been used to treat MM, in which As2O3 generates ROS while ascorbic T-5224 serves as a
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On the other hand a comprehensive gene expression
2018-10-23
On the other hand, a comprehensive gene expression analysis revealed that >300 transcripts exhibited a circadian pattern of oscillation in mouse aorta, indicating that the circadian clock potently regulates a wide range of vascular function (Rudic et al., 2005). Consistent with this, it has been rep
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